In Vitvo Studies on the Relative Sensitivity to Ivermectin of Necator americanus and Ancylostoma ceylanicum
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چکیده
Richards J. C., Rebnke J. M. & Duce I. R. 1995. In uifro studies oo tbe relative sensitivity to ivermectin of Necator americanus and AncyIostoma ceyhnicum. International Journal for Parasitology 25: 1185-1191. Experiments were carried out to compare tbe sensitivity of Ancylostoma ceyhnicum and Necator umericunus to ivermectin (IVM) and pyrantel in vitro. Loss of motility and inhibition of ingestion by IVM were compared and A. ceyhicum was found to be approximately 40-50 times more sensitive to IVM than N. umericunus. Roth species showed a similar sensithity to pyrantel. Uptake of 13HJIVM across tbe cuticle was compared and shown to bc unlikely to account for tbe differences in sensitivity to IVM between tbe two
منابع مشابه
In vitro studies on the relative sensitivity to ivermectin of Necator americanus and Ancylostoma ceylanicum.
Experiments were carried out to compare the sensitivity of Ancylostoma ceylanicum and Necator americanus to ivermectin (IVM) and pyrantel in vitro. Loss of motility and inhibition of ingestion by IVM were compared and A. ceylanicum was found to be approximately 40-50 times more sensitive to IVM than N. americanus. Both species showed a similar sensitivity to pyrantel. Uptake of [3H]IVM across t...
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Experiments were carried out in the hamster to compare the relative susceptibility of Necator americanus and Ancylostoma ceylanicum to treatment with ivermectin. A. ceylanicum was found to be 300 times more sensitive to the anthelmintic with a 50% effective dose (ED50) of the order of 10-15 micrograms kg-1 body weight whilst that for N. americanus approximated to 3-5 mg kg-1. Furthermore, where...
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